In vitro binding studies showed that Sodium Polystyrene Sulfonate Powder, for Suspension bound significantly to the following tested drugs - warfarin, metoprolol, phenytoin, furosemide, amlodipine and amoxicillin. Patients with impaired gag reflex, altered level of consciousness, or patients prone to regurgitation may be at increased risk. Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. Last updated on Nov 1, 2019. : combo may decr. Polystyrene sulfonate affects the exchange of sodium and potassium in the body. You should not use sodium polystyrene sulfonate if you are allergic to it, or if you have: Because sodium polystyrene sulfonate is not absorbed into the bloodstream, this medicine is not expected to be harmful during pregnancy or while nursing a baby. Resonium A contains sodium polystyrene sulfonate which contains sodium atoms. Do not use the medicine orally or rectally in a baby who has slow digestion caused by surgery or by using other medicines. Administer as a warm (body temperature) emulsion in 100 mL of aqueous vehicle and flush with 50 to 100 ml of fluid. Avoid eating or drinking anything that contains sorbitol (a fruit sugar often used as a sweetener in chewing gum, diet drinks, baked goods, or frozen desserts). While using as an oral suspension, it should not be heated or should not be used along with heated foods or liquids, because this may cause a decrease in the effectiveness of this drug. Describes the best time to take the drug and precautions if any that should be followed. Track the Vax: Behind the Scenes of Johnson & Johnson’s Entry in the Race to Beat COVID-19, Exercise, Not Testosterone Therapy, Improves Artery Health in Middle-Aged and Older Men, Tippi Coronavirus: Tips for Living With COVID-19, Kayexalate (Sodium Polystyrene Sulfonate). 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Resonium A contains 99.93% sodium polystyrene sulfonate as a finely ground powder. Call your doctor for medical advice about side effects. Sodium Polystyrene Sulfonate Powder, for Suspension is indicated for the treatment of hyperkalemia. RESONIUM CALCIUM (calcium polystyrene sulfonate) is a cation exchange resin prepared in the calcium phase. Chemical structure. Find patient medical information for sodium polystyrene sulfonate (sorbitol free) oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Do not give this medicine orally (by mouth) to a newborn baby. If your dose is different, do not change it unless your doctor tells you to do so. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. Learn more: Mayo Clinic facts about coronavirus disease 2019 (COVID-19) Our COVID-19 patient … Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem fo… If you or your child are not able to swallow the liquid, the medicine can be given in the stomach using a special tube. In both children and neonates, excessive dosage or inadequate dilution could result in impaction of the resin. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram.The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. sodium polystyrene sulfonate. Sodium polystyrene sulfonate may also be used for purposes not listed in this medication guide. sodium polystyrene sulfonate dosage. KAYEXALATE prescription and dosage sizes information for physicians and healthcare professionals. Cases of intestinal necrosis, some fatal, and other serious gastrointestinal adverse events (bleeding, ischemic colitis, perforation) have been reported in association with Sodium Polystyrene Sulfonate Powder, for Suspension use. The average adult dose is 30 g to 50 g … (A drug class is a group of medications that work in a similar way.) The average total daily adult dose of sodium polystyrene sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Follow all directions on your prescription label and read all medication guides or instruction sheets. Rectal. Use the medicine exactly as directed. A somewhat thicker suspension may be used, but do not form a paste. Avoid inhaling the oral powder while you are preparing a dose. You will need frequent medical tests to help your doctor determine how long to treat you with sodium polystyrene sulfonate. Drugs A-Z provides drug information from Everyday Health and our partners, as well as ratings from our members, all in one place. Avoid using antacids or laxatives without your doctor's advice. Agitate the emulsion gently during administration. Sodium Polystyrene Sulfonate Powder, for Suspension may bind orally administered medications, which could decrease their gastrointestinal absorption and lead to reduced efficacy. This sodium is swapped for potassium in the body, particularly in the large intestine. Use Kayexalate (Sodium Polystyrene Sulfonate) exactly as directed on the label, or as prescribed by your doctor. Side effect rates for Kayexalate (Sodium Polystyrene Sulfonate) 0 reports These are side effects of Kayexalate (Sodium Polystyrene Sulfonate) reported to the FDA by people taking it, … Rectal. The cleansing enema after each rectal dose of this medication should be a non-sodium-containing enema.The dosage … Assess abdomen and note character and frequency of stools. Sodium Polystyrene Sulfonate Suspension USP (SPS ® Suspension) can be administered orally or in an enema. KAYEXALATE is a cation-exchange resin prepared in the sodium phase, with an in vivo exchange capacity of approximately 1 mmol (in vitro approximately 3.1 mmol) of potassium per gram. Discontinue sodium polystyrene sulfonate … However, it is unclear if it is beneficial and there is concern about possible side effects when it is combined with sorbitol. Decreased absorption of lithium and thyroxine have also been reported with co-administration of Sodium Polystyrene Sulfonate Powder, for Suspension. Easy to read FDA package insert, drug facts, dosage and administration, and adverse effects for Kayexalate (Sodium Polystyrene Sulfonate) Skip to: full site navigation. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Mindanao State University – Iligan Institute of Follow the directions on your … Administer Sodium Polystyrene Sulfonate Powder, for Suspension at least 3 hours before or 3 hours after other oral medications. DESCRIPTION. Follow your doctor's orders or the directions on the label. Do not use potassium supplements , calcium supplements , or salt substitutes while you are taking sodium polystyrene sulfonate, unless your doctor has told you to. Mix the powder with 3 to 4 milliliters … The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an . Polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia. The in vivo efficiency of sodium-potassium exchange resins is approximately 33 percent; hence, about one third of the resin's actual sodium content is delivered to the body. The following adverse reactions have been identified during post-approval use of Sodium Polystyrene Sulfonate Powder, for Suspension. Each 15 g dose of Sodium Polystyrene Sulfonate Powder, for Suspension contains 1500 mg (60 mEq) of sodium. Patients with gastroparesis may require a 6 hour separation. Adjustment of other sources of sodium may be required. KAYEXALATE can be administered either orally or as an enema. Patients with gastroparesis may require a 6 hour separation. It is used as a potassium binder in acute and chronic kidney disease for people with hyperkalemia (abnormal high blood serum potassium levels). Pharmacology, adverse reactions, warnings and side effects. Sodium Polystyrene Sulfonate Powder, for Suspension is not totally selective for potassium, and small amounts of other cations such as magnesium and calcium can also be lost during treatment. Monitor for clinical response and/or blood levels where possible. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivoapproximately 1 mEq) of potassium per gram.The sodium … Increase in sodium levels: Sodium polystyrene sulfonate can cause an increase in sodium levels. In in vitro binding studies, Sodium Polystyrene Sulfonate Powder, for Suspension was shown to significantly bind the oral medications (n=6) that were tested. The average adult dose is 30 g to 50 g … SODIUM POLYSTYRENE SULFONATE Kalexate, Kayexalate, K-Exit, Kionex, SPS ACTION Removes potassium by exchanging sodium for potassium in body Therapeutic outcome: Potassium levels within accepted rage USES Hyperkalemia in conjunction with other measures CONTRAINDICATIONS Hypersensitivity to saccharin or parabens that may be in some products; GI obstruction, neonate … This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. This action occurs primarily in the large intestine, which excretes potassium ions to a greater degree than does the small intestine. Learn more about … Keep the enema in the rectum for several hours, if possible. The practical exchange ratio is 1 mEq K per 1 gram of resin. Follow instructions for the use of a cleansing enema both before and after your dose of sodium polystyrene sulfonate. Sodium Polystyrene Sulfonate(Kayexalate) generic is a potassium-removing resin, prescribed for hyperkalemia (without ECG changes). KAYEXALATE prescription and dosage sizes information for physicians and healthcare professionals. Store at room temperature away from moisture and heat. Antacids or laxatives can make sodium polystyrene sulfonate less effective, or cause serious side effects. Select one or more newsletters to continue. Rx Only. Oral Dose: The average daily oral dose … Don't delay your care at Mayo Clinic. Administer Sodium Polystyrene Sulfonate Powder, for Suspension at least 3 hours before or 3 hours after other oral medications. Sodium polystyrene sulfonate starts working over a period of several hours and therefore should not be used to treat life-threatening episodes of acute hyperkalemia. a weak immune system caused using certain medicine; severe constipation or other bowel problems; kidney disease (or if you are on dialysis); an electrolyte imbalance (such as low levels of potassium, calcium, or magnesium in your blood); a bowel disorder, or surgery on your intestines; severe constipation, severe stomach pain, bloating; confusion, thinking problems, feeling irritable. The following information includes only the average doses of this medicine. Take or use sodium polystyrene sulfonate at around the same time (s) every day. Sodium Polystyrene Sulfonate Powder, for Suspension increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. Do not use potassium supplements , calcium supplements , or salt substitutes while you are taking sodium polystyrene sulfonate… (sodium polystyrene sulfonate) POWDER 1 NAME OF THE MEDICINE Resonium A (sodium polystyrene sulfonate). Sodium Polystyrene Sulfonate is contraindicated in the following conditions: patients with hypokalemia, patients with a history of hypersensitivity to polystyrene sulfonate resins, obstructive bowel disease, neonates with reduced gut motility (postoperatively or drug induced) and oral administration in neonates. Sodium polystyrene sulfonate is a cation exchange resin prepared in the sodium phase. The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an in vitro exchange capacity of approximately 3.1 mEq (in vivo approximately 1 mEq) of potassium per gram. Sodium Polystyrene Sulfonate Suspension USP (SPS ® Suspension) can be administered orally or in an enema. If you have congestive heart failure, high blood pressure, kidney problems, or swelling of the ankles, feet, lower legs, or hands, discuss with your doctor how this medication may affect your medical condition and whether special monitoring is required. KAYEXALATE, brand of sodium polystyrene sulfonate is a benzene, diethenyl-polymer, with ethenylbenzene, sulfonated, sodium salt and has the following structural formula: The drug is a cream to light brown finely ground, powdered form of sodium polystyrene sulfonate, a cation-exchange resin prepared in the sodium phase with an . Cases of acute bronchitis or bronchopneumonia caused by inhalation of sodium polystyrene sulfonate particles have been reported. Available for Android and iOS devices. The average total daily adult dose of Sodium Polystyrene Sulfonate Powder, for Suspension is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The information within all other sections is proprietary to Everyday Health. The efficiency of this process is limited and unpredictably variable. Premature infants or low birth weight infants may have an increased risk for gastrointestinal adverse effects with Sodium Polystyrene Sulfonate Powder, for Suspension use [see Warnings and Precautions (5.4)]. Sodium polystyrene sulfonate can be given as a liquid by mouth, through a stomach feeding tube, or as a rectal enema. Polystyrene sulfonate is usually supplied in either the sodium or calcium form. Find everything you need to know about Kayexalate (Sodium Polystyrene Sulfonate), including what it is used for, warnings, reviews, side effects, and interactions. By subscribing you agree to the Terms of Use and Privacy Policy. Sodium polystyrene sulfonate is usually taken or used one to four times a day. Manufacturers advise take other drugs at least 3 hours before or after calcium- or sodium-polystyrene sulfonate; a 6-hour separation should be considered in gastroparesis. exchange Sodium Polystyrene Sulfonate Powder, for Suspension should not be used as an emergency treatment for life-threatening hyperkalemia because of its delayed onset of action [see Clinical Pharmacology (12.2)]. The rectal enema form of this medicine is usually given by a healthcare professional. One small study (n = 13, patient weights 2.4 to 7.5 kg) reports … Overdosage may result in electrolyte disturbances including hypokalemia, hypocalcemia, and hypomagnesemia. Studies of safety and efficacy have not been conducted in pediatric patients. In neonates, Sodium Polystyrene Sulfonate Powder, for Suspension should not be given by the oral route. Advise patients who are taking other oral medication to separate the dosing of Sodium Polystyrene Sulfonate Powder, for Suspension by at least 3 hours (before or after) [see Dosage and Administration (2.1),Warnings and Precautions (5.5), and Drug Interactions (7.1)], sodium bicarbonate, Kayexalate, insulin regular, calcium gluconate, Humulin R, Veltassa. The resin should be retained for as long as possible and follow by a cleansing enema with a nonsodium containing solution. In pediatric patients, as in adults, Sodium Polystyrene Sulfonate Powder, for Suspension is expected to bind potassium at the practical exchange ratio of 1mEq potassium per 1 gram of resin. Sodium polystyrene sulfonate binds itself to potassium in your digestive tract. 28210-41-5 [9003-59-2]. Find out how to take Sodium Polystyrene Sulfonate (drug) and its dose. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. The sodium content is approximately 4.1mmol (100 mg) per gram of Resonium A. Sorbitol may contribute to the risk of intestinal necrosis [see Warnings and Precautions (5.1)] and concomitant use is not recommended. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to estimate their frequency reliably or establish a causal relationship to drug exposure. Oral The average total daily adult dose of Sodium Polystyrene Sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. sodium polystyrene sulfonate + aluminum hydroxide avoid combo w/ oral sodium polystyrene sulfonate or use alternative; interaction less likely w/ rectal admin. in vitro. Suspend each dose in a small quantity of water or syrup, approximately 3 to 4 mL of liquid per gram of resin. Medically reviewed by Drugs.com. [3] Similar changes might occur with breastmilk. Cerner Multum™ provides the data within some of the Overview, Uses, Warnings, Side Effects, Pregnancy, Interactions, Dosage, Overdose, and Images sections. Dosage Forms: oral and rectal powder (-); oral and rectal suspension (15 g/60 mL) … Antacids or laxatives can make sodium polystyrene sulfonate less effective, or cause serious side effects. The enema will be inserted slowly while you are lying down. Each gram of resin has a theoretical in vitro exchange capacity of about 1.3 to 2 millimoles (mmol) of potassium (K+). Resonium A contains 99.93% sodium polystyrene sulfonate as a finely ground powder. Schedule your appointment now for safe in-person care. Data sources include IBM Watson Micromedex (updated 3 Mar 2021), Cerner Multum™ (updated 1 Mar 2021), ASHP (updated 3 Mar 2021) and others. … Dr. Bac Nguyen answered. The average total daily adult dose of sodium polystyrene sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Polystyrene sulfonate is usually supplied in either the sodium or calcium form. The sodium content is approximately 100 mg (4.1 mEq) per gram of the drug. A dosage of 0.5 to 1 g sodium polystyrene sulfonate powder per 100 mL formula/breast milk appears to be a common initial dosage range used. To give this medicine orally: Mix the sodium polystyrene sulfonate powder with water, or with honey or jam to make it taste better. NDC 42806-013-96. Keep using this medicine even if you feel fine. [see Dosage and Administration (2.1) and Drug Interactions (7)]. The simultaneous oral administration of Sodium Polystyrene Sulfonate Powder, for Suspension with nonabsorbable cation-donating antacids and laxatives may reduce the resin's potassium exchange capability and increase the risk of systemic alkalosis. Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SODIUM POLYSTYRENE SULFONATE. sodium polystyrene sulfonate powder, for suspension, We comply with the HONcode standard for trustworthy health information -. The intensity and duration of therapy depend upon the severity and resistance of hyperkalemia. Sodium polystyrene sulfonate: Search drug information, interaction, images & medical diagnosis. Follow instructions for the use of a cleansing enema both before and after your dose of sodium polystyrene sulfonate. approximately 1 mEq) of potassium per gram. View Drug-Study-Sodium-polystyrene-sulfonate.docx from CON NSG105 at Mindanao State University - Iligan Institute of Technology. View All Manufacturers & Suppliers of Sodium Polystyrene Sulfonate API with Drug Master Files (DMF), CEP/COS, Japanese DMFs, Written Confirmation (WC) details listed on PharmaCompass.com sodium polystyrene sulfonate … Sodium Polystyrene Sulfonate increases fecal potassium excretion through binding of potassium in the lumen of the gastrointestinal tract. The suspension may also be given rectally as an enema. Stop using sodium polystyrene sulfonate and call your doctor at once if you have: This is not a complete list of side effects and others may occur. Take or use sodium polystyrene sulfonate at around the same time(s) every day. Comments: -A 15 g dose is equivalent to approximately 4 level teaspoons. Sodium Polystyrene Sulfonate Powder, for Suspension is available as a cream to light brown, finely ground powder in jars of 1 pound (453.6 g). Administer other oral medications at least 3 hours before or 3 hours after Sodium Polystyrene Sulfonate Powder, for Suspension. CAS number. It is a cherry-flavored suspension containing 15 grams of cation-exchange resin (Sodium Polystyrene Sulfonate … Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. The average adult dose is 30 g to 50 g … [2] Addition of large amounts of sodium polystyrene sulfonate to artificial formula also lowers the calcium, copper, manganese, phosphorus, sulfur and zinc concentrations; whereas the iron, sodium and sulfur content of formulas are increased. Monitor serum potassium during therapy because severe hypokalemia may occur. The average adult dose is 30 g to 50 g every six hours. Monitor patients who are sensitive to sodium intake (heart failure, hypertension, edema) for signs of fluid overload. After an initial cleansing enema, insert a soft, large size (French 28) rubber tube into the rectum for a distance of about 20 cm, with the tip well into the sigmoid colon, and tape in place. Resonium A (sodium polystyrene sulfonate). The infants had no clinically noticeable side effects. shouldnt he be having bm? One gram of Sodium Polystyrene Sulfonate Powder, for Suspension contains 4.1 mEq of sodium. The effective lowering of serum potassium with Sodium Polystyrene Sulfonate Powder, for Suspension may take hours to days. You may need to hold in the enema for up to several hours. As the resin passes along the intestine or is retained in the colon after administration by enema, the sodium ions are partially released and are replaced by potassium ions. 1 gram of KAYEXALATE … Sodium Polystyrene Sulfonate Powder, for Suspension is not absorbed systemically. Rectal The average adult dose is 30 g to 50 g every … Both sodium zirconium cyclosilicate and sodium polystyrene sulfonate belong to a drug class known as potassium binders. Sodium Polystyrene Sulfonate Powder, for Suspension is contraindicated in patients with the following conditions: ● Hypersensitivity to polystyrene sulfonate resins. Menu. It can be administered orally or rectally as an enema. The average total daily adult dose of sodium polystyrene sulfonate is 15 g to 60 g, administered as a 15-g dose (four level teaspoons), one to four times daily. Pharmacology, adverse reactions, warnings and side effects. Sodium Polystyrene Sulfonate Powder, for Suspension is a cream to light brown, finely ground powder and is available in 453.6 g jars. Sodium polystyrene sulfonate binds itself to potassium in your digestive tract. Hyperkalemia often has no symptoms that you will notice until your potassium levels are very low. Concomitant administration of sorbitol is not recommended. The sodium polystyrene sulfonate enema is usually followed with a second cleansing enema. No formal drug interaction studies have been conducted in humans. Sodium polystyrene sulfonate is usually taken or used one to four times a day. What is sodium polystyrene sulfonate (Kalexate, Kayexalate, Kionex)? Pharmacodynamics Potassium-removing action: Sodium polystyrene sulfonate is a cation-exchange resin that releases sodium in exchange for other cations in the GI tract. Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension Side effects include: Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention. Sodium polystyrene sulfonate works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. Generic Name: sodium polystyrene sulfonate (SOE dee um pol ee STEER een SUL foe nate) Brand Name: Kalexate, Kayexalate, Kionex. Do not use in larger or smaller amounts or for longer than recommended. Talk to your doctor if you have questions about this. Sodium Polystyrene Sulfonate Dosage & Precautions Before using sodium polystyrene sulfonate, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. It affects the exchange of sodium and potassium in the body. The majority of these cases reported the concomitant use of sorbitol. CMP Pharma, Inc. Cation-Exchange Resin . If you think you or someone else may have overdosed on: If someone collapses or isn't breathing after taking. However, it is unclear if it is beneficial and there is concern about possible side effects … Dosage is individualized and depends on daily assessment of total body potassium. This helps prevent your body from absorbing too much potassium. © 1996-2021 Everyday Health, Inc. The average daily adult dose of the resin is 15 to 60 grams. The sodium content is approximately 4.1 mmol (100 mg) per gram of the drug. The dose of this medicine will be different for different patients. in vitro . 2 Qualitative and Quantitative Composition. Schedule your appointment now for safe in-person care. This helps prevent your body from absorbing too much potassium. Appropriate measures should be taken to correct serum electrolytes (potassium, calcium, magnesium), and the resin should be removed from the alimentary tract by appropriate use of laxatives or enemas. exchange capacity of approximately 3.1 mEq (in vivo . Store at 20° to 25°C (68° to 77°F) [see USP Controlled Room Temperature]. Rectal. Binding of Sodium Polystyrene Sulfonate Powder, for Suspension to other oral medications could cause decreased gastrointestinal absorption and loss of efficacy when taken close to the time Sodium Polystyrene Sulfonate Powder, for Suspension is administered. Maximum dose: 15 g orally 4 times a day. Schedule your appointment now for safe in-person care. Risk factors for gastrointestinal adverse events were present in many of the cases including prematurity, history of intestinal disease or surgery, hypovolemia, and renal insufficiency and failure. It is used as a potassium binder in acute and chronic kidney disease for people with hyperkalemia (abnormal high blood serum potassium levels). Do not heat Sodium Polystyrene Sulfonate Powder, for Suspension as it could alter the exchange properties of the resin. What are the possible side effects of sodium polystyrene sulfonate … Sodium polystyrene sulfonate is used to treat high levels of potassium in the blood, also called hyperkalemia.

Port Adelaide Membership Prices 2021, Placid Meaning In Tagalog, Child Tax Credit Phase Out 2021, Definisi Biseksual Malaysia, Quint Consulting Services, Vancouver Night Skiing, Whataburger Work Schedule App,